Research: Kind 2 diabetes medicine could also be used to deal with autoimmune illness – ET HealthWorld

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Research: Kind 2 diabetes medicine could also be used to deal with autoimmune illness – ET HealthWorld


Washington: A drug usually used to deal with sort 2 diabetes, in response to analysis from Swansea College, may additionally be used to deal with autoimmune illnesses.

Lecturers on the College’s College of Drugs, Well being and Life Science have discovered that the drug, canagliflozin (also referred to as Invokana), may very well be used to deal with autoimmune issues corresponding to rheumatoid arthritis and systemic lupus erythematosus because it targets T-cells, which type a vital part of the immune system. Canagliflozin is a drug that controls blood sugar ranges in individuals with sort 2 diabetes, nonetheless researchers have discovered an sudden position for the drug involving the human immune system.

Present analysis has reported that focusing on T-cell metabolism in autoimmunity can result in therapeutic advantages. T-cells are a sort of white blood cell that assist the physique combat infections and illnesses, however in autoimmune illnesses they’ve been noticed to assault wholesome tissues.

The brand new research, funded by the Medical Analysis Council and printed at present within the journal Cell Metabolism, discovered that canagliflozin dampens down T-cell activation, suggesting that the drug may very well be repurposed as a remedy for T-cell pushed autoimmunity.Dr Nick Jones, senior creator who led the research mentioned: “Our findings are vital as they supply the inspiration for the scientific improvement of canagliflozin for the remedy of sure autoimmune illnesses. Because the drug is already broadly used and has a identified security profile in people, it may doubtlessly attain clinic faster than any new medicine developed and produce priceless advantages extra swiftly to sufferers with autoimmune issues.”

Ben Jenkins, first creator and postdoctoral researcher at Swansea mentioned: “Figuring out new roles for medicine which might be presently being utilized in different illness settings is an thrilling space of analysis. Provided that our analysis primarily targets the metabolism of immune cells, we hope that the potential therapeutic advantages of our findings are relevant to a variety of situations.”

The researchers are hopeful that canagliflozin will enter a scientific trial to deal with sure autoimmune issues sooner or later.

  • Revealed On Might 29, 2023 at 02:13 PM IST

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